Adisseo

Efficacy of Sanacore® against white feces syndrome

07/29/2019

White feces syndrome (WFS) is considered a major cause of significant crop failures of white shrimp in Asia. Multiple pathogenic combinations have been associated to the disease, including Vibrio spp. bacteria and microsporidian parasites such as Enterocytozoon hepatopenai (EHP). The dietary inclusion of functional feed additives that deliver antimicrobial and antiparasitic activities to the digestive system and boost the immune system can be a strategy to prevent and help to control infection. Adisseo has looked into the efficacy of Sanacore®, a phytobiotic-based feed additive, against WFS causative pathogens. Under in vivo and in vitro infection models in controlled laboratory conditions, Sanacore® proved to reduce the prevalence of gross signs of infection and mortality by 50% and 40%, respectively, as well as to inhibit germination of EHP spores. This efficacy was further validated under field conditions in different farms located in Indonesia, Malaysia and India, showing that the combination of preventive and corrective dosages of Sanacore®in feed can maintain or bring up growth rates and survival to pre-WFS levels. This work describes a new solution for feed mills and farmers to reduce the likelihood and severity of WFS outbreaks.

Tilapia tolerate adverse conditions and stressors better than most commercial aquaculture species. However, current rearing conditions (i.e. high densities, water temperature and quality, etc.) induce a stress level that is detrimental to the animal´s immune system and that, in combination with the presence of pathogens, results in disease outbreak. Streptococcosis and franciselosis are two bacterial diseases associated to temperature fluctuations during the summer and winter periods and that cause high mortality in tilapia culture. In a recent article published in Aquafeed (vol 12, issue 1, 2020), the efficacy of Sanacore® GM against these two bacterial diseases was demonstrated.

In vitro results showed reduced number of bacterial cells and changes in their morphology. In vivo data proved a growth promoting effect just after 20 days of supplementation as well as significant reductions in mortality of 32% and 17% against infection by against Streptococcus agalactiae and Francisella noatunensis subsp orientalis, respectively.

This article further demonstrates the preventive efficacy of Sanacore® against bacterial infection and some of its modes of action underlying these improvements.

 

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