Our rumen protected Methionine: Smartamine® M & MetaSmart®

Smartline™: Smartamine® M & MetaSmart®

Methionine is an essential nutrient and generally is the first limiting amino acid for dairy cows. Meeting methionine requirements results in higher production, better metabolic health, and improved reproduction performance.

Because the methionine content of feedstuffs is generally low, supplemental methionine should be fed to meet the cow’s nutritional requirements. This allows the proper balance of amino acids to be achieved in the ration at an optimal feed cost; helps reduce nitrogen excretion; and helps improve production, health, and reproduction.

  • Smartamine® M, a coated methionine with specific pH-sensitive polymer  that protects the amino acid during its passage through the rumen, ensuring its release in the abomasum and absorption in the small intestine.

  • MetaSmart®, a unique source of specific, pelletable methionine for ruminants. MetaSmart® delivers excellent bio-availability and provides the needed methionine for the rumen microorganisms.

Benefits of Supplemental Methionine

Smartamine® M & MetaSmart® allow nutritionists, feed manufacturers, and premix companies to provide dairy nutrition solutions that involve amino acid balancing. These products contain methionine, an essential nutrient, that is known to enable:

  1. Milk production with increased protein and higher fat

  2. Greater feed efficiency

  3. Better metabolic health and reproduction


Methionine is key to meeting requirements for milk performance and also plays essential roles in other metabolic functions. These include helping to ensure optimum reproductive performance and liver function. Supplying adequate quantities of methionine is critical for transition cows to eat adequate amounts to meet their energy needs for production while helping to minimize metabolic issues such as fatty liver and ketosis.

Smartamine® M Rumen Protected Methionine

Smartamine® M, a coated methionine designed for ruminants and in particular dairy cows, is an exclusive product patented by Adisseo. Its small beads of methionine are covered with a specific pH-sensitive coating. This unique coating protects the amino acid during its passage through the animal’s rumen.

Once the Smartamine® M passes through the rumen, the coating breaks down and the methionine is released in the abomasum, the ruminant’s last stomach. This enables the absorption of methionine in the small intestine for passage into the bloodstream and use by the cow.


Nutrition consultants, premix companies, and/or feed manufacturers use Smartamine M. They use it as an innovative solution in nutritional strategies to allow a dairy herd’s production performance to be realized as well as more of the herd’s full genetic potential.

More information on Smartamine® M

MetaSmart® Methionine for Pelleted and Liquid Feeds

MetaSmart®, an ester of the analogue of methionine, is a unique feed ingredient and patented molecule from Adisseo. It is designed to optimize amino acid balancing in dairy cow rations and; and can be utilized in multiple types of feeds including pelleted and liquid feed for ruminants.

MetaSmart®, delivers two modes of action:

  • Rumen Wall Absorption (50% bioavailable): 50% of MetaSmart®, is absorbed across the rumen wall to provide the supplementary methionine necessary to optimize milk protein synthesis and metabolic health.

  • Rumen Activation (50% bioavailable): 50% of MetaSmart®, is hydrolyzed in the rumen to the analogue of methionine. The analogue has been shown to have a positive benefit on rumen fermentation increasing the energy contribution of feeds and increasing the microbial protein supply.

As per the scheme below, only MetaSmart®, supplies methionine for both the animal’s requirements: It’s 50% bioavailable and 50% rumen active.

Whether you choose Smartamine® M or MetaSmart®, Adisseo is dedicated to delivering reliable nutritional solutions that will optimize the methionine status of your animals necessary for cow performance and health.

More information on Smartamine® M

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30th Anniversary of Amino Acid Balancing for lifetime performance

Each webinar celebrates the 30th anniversary of amino acid balancing. We are thrilled to present engaging conversations in which leading industry and Adisseo experts discuss topics related to amino acid balancing.


ADSA Abstracts

Each podcast contains highlights of ruminant research sponsored by Adisseo and presented during the  American Dairy Science Association (ADSA) Annual Meeting.

Highlights include what was researched and why, a brief summary of the findings, the conclusions drawn, and insights on how best to apply the results.

Click on the year button to access the page: 202320222021

Ruminants Transition Health Videos and Podcasts

Each video and podcast presents a solution to a potential health concern for transition dairy cows. Through engaging conversations, leading industry and Adisseo experts discuss transition health concerns, the impact on transition cows, and a practical Adisseo solution.

Basics of Methionine key role for Ruminants in video

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Ruminants experts conversations on FeedChannel

FeedChannel is a dedicated media platform for the feed world. It was launched in 2016 and has since grown alongside major events in Animal Nutrition.

The platform offers a focus on industry issues and provides insights from Opinion Leaders and International Scientists.

You can access videos related to subjects like: Amino Acido Balancing, Transition Health, Heat Stress or Herd Longivity.


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Adisseo provides its customers with PNE, a unique service based on NIR technology to predict the nutritional quality of the raw materials used in feed. Adisseo is able to analyze all main dietary ingredients to predict in real time the multiple characteristics impacting nutritional quality, using a reliable system based on in vivo data.

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Latest Product News

  • Adisseo Stresses Importance of Amino Acid Balancing in Fight to Meet Dairy Sustainability Goals
  • Lifetime performance improves when feeding rumen-protected methionine
    Extensive research over the last three decades shows that feeding supplemental, encapsulated methionine increases the lifetime performance of dairy cows with the benefits first seen in milk, milk protein and milk fat production. By precisely balancing amino acid levels in the ration, nutritionists can economise the total protein level fed. Read more
  • Methionine can lessen the negative effects of health disorders
    METHIONINE is a functional amino acid, meaning that it regulates important biological functions other than just serving as a building block for proteins. For instance, methionine plays an important role in the antioxidative defense that is positively associated with health status of animals. In dairy cows, one question that had Read more
  • 30 Years On: Adisseo Emphasizes the Importance of Rumen Protected Methionine in Dairy Nutrition
    January 2023 While amino acid balancing has been common practice in monogastric nutrition for decades, its mainstream adoption by the dairy industry has trailed behind. And this despite rumen-protected methionine solutions being around since the 1990s, which greatly improved the ability to formulate dairy diets based on this first limiting, Read more
  • The Contrasting Functions of Nutrition on Reproduction in Dairy Cows Webinar on October 27th 2022
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