Fluctuating contexts and challenges, such as temperature variation, high density, or new pathogens, present ongoing hurdles in livestock farming, increasing the negative impact of bacteria on animal health.
In addition to this, the restriction on antibiotic usage further complicates pathogen management strategies.
One solution to maintain performance within challenged conditions is the implementation of animal resilience concept.
Watch our insightful webinar as Prof. Charlotte Lauridsen and Dr. Tim Goossens share expert insights on tackling Escherichia Coli in swine, addressing neonatal and post-weaning colibacillosis to help safeguard piglet health and reduce economic losses.
Within the realm of microbiological contamination, mycotoxins such as aflatoxins, deoxynivalenol, and zearalenone are of particular concern for swine. Mycotoxins pose health risks to animals, compromising growth and reproduction performance. They increase susceptibility to illness due to immune suppression or are even responsible for damaging organs. Still at low levels (below regulatory limits), mycotoxins can have an impact on animal growth. The prolonged stress induced by mycotoxins is an aggravating factor for infections and the prevalence of pathogens, among others.
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Pigs face regular exposure to environmental stimuli. Stressful stimuli, such as weaning, temperature variation, high density, lead to stress and be perceived as a threat. At the cell level, a stressful environment triggers the release of stress hormones, increases free radicals’ production and overwhelms the body’s antioxidant defense system, leading to oxidative stress. The repercussions of stress encompass changes in biological function, resulting in decreased performance.
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Gut barrier function is crucial for protecting against pathogens pressure and maintaining homeostasis. However, factors such as infectious agents, environmental stressors, and other challenges compromise the integrity of the gastrointestinal tract, rendering animals more susceptible to outbreaks of bacterial diseases. This can result in decreased performance, growth, and reproduction, and in severe cases, mortality.
Understanding the gut barrier function is the initial step in ensuring animal resilience. Preserving the stability of gut microbiota is crucial for maintaining gut equilibrium and preventing infections. This can be achieved through direct antimicrobial action, collaboration with the immune system, or counteracting tactics developed by pathogens for their survival. Strengthening the physical barrier involves preserving permeability and tight epithelial junctions. Regulating inflammation is essential for influencing immune response balance by leveraging the role of the immune system: surveillance, detection, defensive reaction, and elimination of foreign agents.
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